A web database of the Italian genetic variability

Believing in the utility of large population-specific databases, especially for a complex population like the Italian one, the Network for Italian Genomes (NIG) provides variant frequencies as a free tool for both clinicians and researchers.

Four datasets are currently available for direct searches (4212 exomes and 380 genomes):

• 1492 Italian clinical cases and trios affected by different diseases (NIG);
• 1686 Italian healthy controls, with well-characterized ancestry in the four Italian macro-areas: North, Center, South and Sardinia (NIG-ExIT);
• 1034 Italian SARS-CoV-2 PCR positive individuals (1013 unrelated), from very severe (intubated) to asymptomatic cases (NIG-COVID);
• 385 Italian individuals with Whole Genome Sequencing from the Orchestra Project (NIG-WGS).